Abstract
AN attractive explanation of the post-activation potentiation found at the neuromuscular junction is that the presynaptic impulse, in addition to producing a momentary synchronous release of miniature potentials—the endplate potential—causes mobilization of further transmitter signalled by an increase in the frequency of the spontaneous miniature discharge1. This hypothesis, if confirmed, would be of great importance in understanding the mechanism of transmitter release. It has therefore been investigated by studying changes in the frequencies of the miniature potential and in the size of the parallel endplate potential after conditioning by one to five thousand volleys, using a wide range of stimulating frequencies.
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References
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HUBBARD, J. Post-activation Changes at the Mammalian Neuromuscular Junction. Nature 184, 1945–1947 (1959). https://doi.org/10.1038/1841945a0
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DOI: https://doi.org/10.1038/1841945a0
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