Abstract
THE actinomycins (I to V)1 synthesized by Streptomyces antibioticus each possess two moles of D-valine per mole of antibiotic2; Streptomyces chrysomallus, on the other hand, forms a mixture consisting of actinomycins IV (contains 2 moles D-valine), VI (contains l mole D-valine and l mole D-alloisoleucine) and VII (contains 2 moles D-alloisoleucine)2. During an investigation concerned with the mechanism of synthesis of D-amino acids by S. antibioticus, it was observed that the addition of D-valine to a chemically-defined medium3 in which the organism was growing resulted in a marked inhibition of actinomycin synthesis (Table 1, Fig. 1). The relationship of this event to that seen in penicillin biosynthesis with D-valine4,5 prompted a further investigation of this phenomenon.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Waksman, S. A., Katz, E., and Vining, L. C., Proc. U.S. Nat. Acad. Sci., 44, 602 (1958).
Johnson, A. W., Ciba Foundation Symp., 123 (London, 1958).
Katz, E., and Goss, A. W., Nature, 182, 1668 (1958).
Demain, A., Arch. Biochem. and Biophys., 64, 74 (1956).
Arnstein, H. R. V., and Margreiter, H., Biochem. J., 68, 339 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KATZ, E. Inhibition of Actinomycin Synthesis by D-Valine. Nature 184, 1666–1668 (1959). https://doi.org/10.1038/1841666a0
Issue Date:
DOI: https://doi.org/10.1038/1841666a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
