Letter | Published:

Skin Homografts in Parabiotic Mice


THE failure to obtain successful homografts in non-related individuals of the same species is due to antigenic differences occurring between the donor and the recipient on the basis of which the specific immunulogical reaction, transplantation immunity, results. Tissue incompatibility can be overcome either by physical, chemical or biological treatment of the transplant itself diminishing its antigenic diversity in relation to the recipient or by changes in the immunological reactivity of the recipient against the antigens of the transplanted tissues. Hitherto the best method of opposing tissue incompatibility and theoretically the most significant is the experimentally acquired tolerance of the foreign antigens elicited by the action of these antigens on the organism in its early ontogenic stages. This can be accomplished by means of intra-embryonal injections of homologous cells1, of injections in new-born animals in the ‘adaptative period’2, by experimental parabiosis in birds3 and by exsanguination blood transfusion performed shortly after the birth4.

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