Letter | Published:

Growth-Controlling Action of Human Serum in Cell Culture

Abstract

IT is reasonable to think that there are stimuli and opportunities in every human life which result in a cancerous transformation of some cells. The main factor in the progress of these cells to the clinical tumour stage might be a deficiency in the growth-controlling defensive mechanism. To demonstrate the possible existence of such factors we have studied since 1955 the effect of human serum on different cells in cell culture1.

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References

  1. 1

    Penttinen, K., and Saxén, E., Ann. Med. Exp. Fenn., 34, 22 (1956); 34, 396 (1956); 35, 335 (1957). Penttinen, K., Saxén, E., Saxén, L., Toivonen, S., and Vainio, T., ibid., 36, 27 (1958).

  2. 2

    Vainio, T., and Pentteinen, K., ibid., 37, 18 (1959).

  3. 3

    Cailleau, R., and Kirk, P. L., Texas Rep., 2, 237 (1957). Bolande, R. P., and Todd, E. W., Arch. Path., 66, 720 (1958). Fedoroff, S., J. Lab. Clin. Med., 48, 55 (1956).

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    Norris, E. R., and Majnarich, J. J., Amer. J. Phsiol., 153, 492 (1948).

  5. 5

    Southam, C. M., Moore, A. E., and Rhoads, C. P., Proc. Amer. Ass. Cancer Res., 2, 251 (1957).

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