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Growth-Controlling Action of Human Serum in Cell Culture


IT is reasonable to think that there are stimuli and opportunities in every human life which result in a cancerous transformation of some cells. The main factor in the progress of these cells to the clinical tumour stage might be a deficiency in the growth-controlling defensive mechanism. To demonstrate the possible existence of such factors we have studied since 1955 the effect of human serum on different cells in cell culture1.

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  1. 1

    Penttinen, K., and Saxén, E., Ann. Med. Exp. Fenn., 34, 22 (1956); 34, 396 (1956); 35, 335 (1957). Penttinen, K., Saxén, E., Saxén, L., Toivonen, S., and Vainio, T., ibid., 36, 27 (1958).

  2. 2

    Vainio, T., and Pentteinen, K., ibid., 37, 18 (1959).

  3. 3

    Cailleau, R., and Kirk, P. L., Texas Rep., 2, 237 (1957). Bolande, R. P., and Todd, E. W., Arch. Path., 66, 720 (1958). Fedoroff, S., J. Lab. Clin. Med., 48, 55 (1956).

  4. 4

    Norris, E. R., and Majnarich, J. J., Amer. J. Phsiol., 153, 492 (1948).

  5. 5

    Southam, C. M., Moore, A. E., and Rhoads, C. P., Proc. Amer. Ass. Cancer Res., 2, 251 (1957).

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