Letter | Published:

Determination of Chlorine in Muscle Tissues by Neutron Activation Analysis


NEUTRON activation analysis permits the determination of sodium, potassium and phosphorus in exceedingly small samples of tissues, for example, needle biopsy material from human skeletal muscle1. Such measurements may be of value for the investigation of the electrolyte content of the cells. However, determination of the chloride content of the tissues would also be of great interest. The chlorides are predominantly present in the extracellular fluid and, thus, by determination of the chlorides in whole tissues and in plasma the distribution of electrolytes and water between cells and extracellular fluid can be calculated2.

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  1. 1

    Reiffel, L., and Stone, C. A., J. Lab. Clin. Med., 49, 286 (1957).

  2. 2

    Manery, J. F., Physiol. Rev., 34, 334 (1954).

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