Abstract
DURING preliminary experiments attempting to extract deoxyribonucleic acid from vaccinia virus by various physical and chemical means, we incidentally observed that after exposure to 8 M urea the infectious properties of the virus were rapidly lost in the cold, whereas the hæmagglutinin titre was not reduced even after several hours at 37° in the presence of the reagent. These findings seemed sufficiently interesting to prompt the further investigations described in this communication.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gillen, A. L., Burr, M. M., and Nagler, F. P., J. Immunol., 65, 701 (1950).
Stone, J. D., Aust. J. Exp. Biol. Med. Sci., 24, 191 (1946).
McCrea, J. F. (unpublished results).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McCREA, J., O'LOUGHLIN, J. Effect of Concentrated Urea Solutions on the Infectivity and Hæmagglutinin of Vaccinia Virus. Nature 184, 1497–1498 (1959). https://doi.org/10.1038/1841497a0
Issue Date:
DOI: https://doi.org/10.1038/1841497a0
This article is cited by
-
Harnstoff-Extrakte aus gramnegativen Bakterien in der indirekten Hämagglutinationsreaktion
Zeitschrift für Hygiene und Infektionskrankheiten (1961)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
