Letter | Published:

Effect of Concentrated Urea Solutions on the Infectivity and Hæmagglutinin of Vaccinia Virus


DURING preliminary experiments attempting to extract deoxyribonucleic acid from vaccinia virus by various physical and chemical means, we incidentally observed that after exposure to 8 M urea the infectious properties of the virus were rapidly lost in the cold, whereas the hæmagglutinin titre was not reduced even after several hours at 37° in the presence of the reagent. These findings seemed sufficiently interesting to prompt the further investigations described in this communication.

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    Gillen, A. L., Burr, M. M., and Nagler, F. P., J. Immunol., 65, 701 (1950).

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    Stone, J. D., Aust. J. Exp. Biol. Med. Sci., 24, 191 (1946).

  3. 3

    McCrea, J. F. (unpublished results).

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