Letter | Published:

Spontaneous De-amination of Amino-acid Phosphates under Physiological Conditions


AMINO-ACIDS are stable compounds which undergo de-amination only under drastic preparative conditions. De-amination of amino-acids in aqueous solutions, at physiological pH, and at room temperature occurs only in the presence of enzyme systems or by irradiation. The well-known enzymatic de-aminations are oxidative de-aminations leading to the formation of keto-acids and non-oxidative de-aminations yielding fatty acids and sometimes hydroxy acids.

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    Katchalsky, A., and Mella Paecht, J. Amer. Chem. Soc., 76, 6042 (1954).

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