Abstract
IN the course of experimental work we found it necessary to administer a standard dose of D-tubo-curarine chloride to the same cat on several occasions over a period of months. We observed that in the fifteen animals studied the duration of paralysis of respiratory and other muscle groups became steadily shorter. The work was all done on the intact animal in a warm room. Nitrous oxide in 3 : 1 mixture with oxygen was the sole anæsthetic agent used—thus, in the preliminary stages no drug was involved which was likely to influence the duration of neuromuscular block. D-tubocurarine was administered intravenously in doses of 0.6 mgm./kgm., and during the period of respiratory paralysis artificial respiration was maintained through an endotracheal tube at a rate of 20–25 per min., a soda lime canister being included in the circuit for the absorption of carbon dioxide. In this way adequate oxygenation was maintained throughout all experiments.
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Bigland, B., and Zaimis, E., J. Physiol., 141, 420 (1958).
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ACHESON, F., FRY, R. Induced Tolerance to D-Tubocurarine Chloride in the Cat. Nature 184, 1409 (1959). https://doi.org/10.1038/1841409a0
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DOI: https://doi.org/10.1038/1841409a0
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