Abstract
THIOCTIC ACID (lipoic acid, DL-6-8 dithiooctinoic acid) is known to be a component of certain enzyme systems. It is also required as a growth factor by Streptococcus fœcalis in certain synthetic media, if this organism is to oxidize pyruvate successfully. Certain other bacteria, such as Escherichia coli, that oxidize pyruvate also require thioctic acid1. It has been tested for its ability to stimulate growth in higher animals; but the results have not been uniform. Positive results were obtained by DeBusk and Williams2 with rats and chicks. In their experiments a growth response was obtained whether the basal ration was a practical corn-soybean-alfalfa meal type or a purified sucrose–alcohol extracted casein-gelatin type. Feed efficiency was also improved with both the chicks and the rats.
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References
Baldwin, E., “Dynamic Aspects of Biochemistry”, Third edit. (Cambridge University Press, 1957).
DeBusk, B. G., and Williams, R. J., Arch. Biochem. Biophys., 55, 587 (1955).
Briggs, G. M., and Fox, M. R. S., Poultry Sci., 36, 657 (1957).
Kratzer, F. H., Vohra, P., Davis, P. N., and Atkinson, R. L., Poultry Sci., 37, 955 (1958).
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JOWSEY, J., BLAKELY, R. & MACGREGOR, H. Effect of Thioctic Acid on Gain in Body-Weight by Turkey Poults. Nature 184, 1323–1324 (1959). https://doi.org/10.1038/1841323b0
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DOI: https://doi.org/10.1038/1841323b0
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