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Effect of Sulphonamides on the Phagocytic Activity of the Reticulo-Endothelial System

Nature volume 184, pages 1241–1242 (1959)Cite this article

Abstract

THE effect of various steroids, stilbenes, antibiotics and other substances on the phagocytic activity of the reticulo-endothelial system has been reported previously by Nicol and his co-workers1,2,3. It was shown that some of these substances stimulate the reticulo-endothelial phagocytes, some have little or no effect, and some are active depressants. So far, diethylstilbœstrol has been found to be the strongest stimulant and cortisone the most powerful depressant. Florey4 has stated that it is possible that some chemotherapeutic agents depend for their complete effectiveness on the action of phagocytes. In this connexion it may be stated that our results with antibiotics3 showed that these substances have little or no effect on the phagocytosis of particulate carbon.

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References

  1. Bilbey, D. L. J., and Nicol, T., Nature, 182, 674 (1958).

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  2. Nicol, T., Bilbey, D. L. J., and Ware, C. C., Nature, 181, 1538 (1958).

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  3. Sewell, I. A., and Nicol, T., Nature, 181, 1662 (1958).

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  4. Florey, H., ‘General Pathology’ (Lloyd-Luke, London, 1958).

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  5. Biozzi, G., Benacerraf, B., and Halpern, B. N., Brit. J. Exp. Path., 34, 441 (1953).

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Authors and Affiliations

  1. Department of Anatomy, King's College, London, W.C.2

    T. NICOL & I. A. SEWELL

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  1. T. NICOL
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  2. I. A. SEWELL
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NICOL, T., SEWELL, I. Effect of Sulphonamides on the Phagocytic Activity of the Reticulo-Endothelial System. Nature 184, 1241–1242 (1959). https://doi.org/10.1038/1841241b0

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