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Decrease in Radiosensitivity of the Intact Mouse Spleen produced by Hypoxia

Abstract

THE radio-protective effects of low oxygen tensions in tissues during exposure to X-rays has been described by Gray and his associates1. Wright and Howard-Flanders2 have demonstrated the protective action of severe hypoxia on the irradiated mouse-tail, and Wright3 has observed increased resistance of the intact mouse thymus, irradiated while the animal was breathing nitrogen.

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References

  1. Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., and Scott, O. C. A., Brit. J. Radiol., 26, 638 (1953).

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  2. Wright, E. A., and Howard-Flanders, P., Acta Radiol., 48, 26 (1957).

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  3. Wright, E. A., Brit. J. Radiol., 32, 168 (1959).

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  4. Carter, R. E., Harris, P. S., and Brennan, J. T., Los Alamos Sci. Lab. Rep. LA-1075 (1950).

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WEISS, L. Decrease in Radiosensitivity of the Intact Mouse Spleen produced by Hypoxia. Nature 184, 1156–1157 (1959). https://doi.org/10.1038/1841156b0

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