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Deoxyribonucleic Acid Formation in Multiplying HeLa Cells


WHILE studying the behaviour of parasynchronously dividing HeLa cells (Gey), Newton and Wildy1 have measured the amount of deoxyribonucleic acid as a function of the time-interval between one division and the next. Their results suggest that the synthesis of deoxyribonucleic acid occurs during two periods in interphase: one soon after and one just before cell division. Between these periods, in mid interphase, there exists an interval during which the amount of deoxyribonucleic acid (DNA) in the cell remains approximately constant (Fig. 1, curve a).

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SMITH, C., NEWTON, A. & WILDY, P. Deoxyribonucleic Acid Formation in Multiplying HeLa Cells. Nature 184, 107–108 (1959).

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