Abstract
PROFLAVINE inhibits the growth of bacterial viruses by blocking some process or processes connected with the formation of the infective virus particle from its sub-units. Antigens, specific to the virus, are still synthesized in the presence of proflavine although fully infective virus particles are not produced. These observations have also been made with some animal viruses (vaccinia1,2, fowl plague3, poliomyelitis4). The action of proflavine is regarded as being due to the inhibition of cytoplasmic protein synthesis, but Dulbecco and Vogt5 have shown that low concentrations of proflavine induce mutations in the virus of poliomyelitis, so the compound probably has some action on the nucleic acid of this virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Thompson, R. L., J. Immunol., 55, 345 (1947).
Briody, B. A., and Stannard, C., J. Immunol., 67, 423 (1951).
Franklin, R. M., Virology, 6, 525 (1958).
Ledinko, N., Virology, 6, 512 (1958).
Dulbecco, R., and Vogt, M., Virology, 5, 236 (1958).
Brown, F., and Stewart, D. L., Virology, 7, 408 (1959).
Cartwright, Sheila F., and Thorne, H. V., J. Gen. Microbiol., 20, 61 (1959).
Gierer, A., and Schramm, G., Nature, 177, 702 (1956).
Galloway, I. A., Fifth Progress Report Foot-and-Mouth Disease Research Committee, Appendix III, p. 342 (H.M. Stationery Office, London, 1937).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BROWN, F., STEWART, D. Effect of Proflavine on the Formation of the Virus of Foot-and-Mouth Disease and its Infective Ribonucleic Acid in Pig Kidney Tissue Culture Monolayers. Nature 184, BA74–BA75 (1959). https://doi.org/10.1038/184074a0
Issue Date:
DOI: https://doi.org/10.1038/184074a0
This article is cited by
-
The effect of proflavine on rubella virus replication in Raby hamster kidney (BHK-21) cells
Archiv f�r die gesamte Virusforschung (1972)
-
Inhibition of Protein Synthesis by Acridine Orange
Nature (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
