Effect of Proflavine on the Formation of the Virus of Foot-and-Mouth Disease and its Infective Ribonucleic Acid in Pig Kidney Tissue Culture Monolayers

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Abstract

PROFLAVINE inhibits the growth of bacterial viruses by blocking some process or processes connected with the formation of the infective virus particle from its sub-units. Antigens, specific to the virus, are still synthesized in the presence of proflavine although fully infective virus particles are not produced. These observations have also been made with some animal viruses (vaccinia1,2, fowl plague3, poliomyelitis4). The action of proflavine is regarded as being due to the inhibition of cytoplasmic protein synthesis, but Dulbecco and Vogt5 have shown that low concentrations of proflavine induce mutations in the virus of poliomyelitis, so the compound probably has some action on the nucleic acid of this virus.

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BROWN, F., STEWART, D. Effect of Proflavine on the Formation of the Virus of Foot-and-Mouth Disease and its Infective Ribonucleic Acid in Pig Kidney Tissue Culture Monolayers. Nature 184, BA74–BA75 (1959) doi:10.1038/184074a0

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