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Positive Inotropic Activity of Cytidine Triphosphate


ALTHOUGH nucleotides other than those of adenyl origin have been isolated from muscle1, physiologists, when considering the events associated with the contraction-relaxation cycle, have assigned a dominant role to the adenosine derivatives—in particular to adenosine triphosphate2. It was therefore interesting to note that cytidine triphosphate exerted a marked positive inotropic action on isolated perfused toad hearts.

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NAYLER, W., McCULLOCH, M. Positive Inotropic Activity of Cytidine Triphosphate. Nature 184, 67–68 (1959).

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