Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Increased Circulating Insulin-like Activity in Obese-Hyperglycæmic Mice

Nature volume 184, pages 61–62 (1959)Cite this article

Abstract

THE hereditary obese-hyperglycæmic syndrome of mice is a condition characterized by extreme adiposity, hyperglycæmia, hypercholesterolæmia, and a variety of metabolic, endocrine, enzymatic and behavioural idiosyncrasies1–3. High blood glucose values are observed under conditions of ad libitum feeding in spite of an increased insulin content of the pancreas, extensive hypertrophy of the islets of Langerhans and marked hyperplasia and degranulation of the beta-cells4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mayer, J., Physiol. Revs., 33, 472 (1953).

    Article  CAS  Google Scholar 

  2. Mayer, J., Nutr. Abstr. and Revs., I, 25, 597; II, 25; 871 (1955).

    CAS  Google Scholar 

  3. Mayer, J., Metabolism, 6, 435 (1957).

    CAS  Google Scholar 

  4. Wrenshall, G. A., Andrus, S. B., and Mayer, J., Endocrinol., 56, 335 (1955).

    Article  CAS  Google Scholar 

  5. Martin, D. B., Renold, A. E., and Dagenais, Y. M., Lancet, ii, 76 (1958).

  6. Winegrad, A. I., and Renold, A. E., J. Biol. Chem., 233, 273 (1958).

    CAS  PubMed  Google Scholar 

  7. Mayer, J., (to be published).

  8. Nelson, N., J. Biol. Chem., 153, 375 (1944).

    CAS  Google Scholar 

Download references

Author information

Author notes

  1. JEAN CHRISTOPHE: Holder of a research fellowship, supported in part by the International Co-operation Administration under a programme administered by the National Academy of Sciences.

Authors and Affiliations

  1. Department of Nutrition, Harvard School of Public Health,

    JEAN CHRISTOPHE, YVES DAGENAIS & JEAN MAYER

  2. Baker Clinic Research Laboratory in the Department of Medicine, Harvard Medical School, Boston, Mass.

    JEAN CHRISTOPHE, YVES DAGENAIS & JEAN MAYER

Authors
  1. JEAN CHRISTOPHE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. YVES DAGENAIS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. JEAN MAYER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHRISTOPHE, J., DAGENAIS, Y. & MAYER, J. Increased Circulating Insulin-like Activity in Obese-Hyperglycæmic Mice. Nature 184, 61–62 (1959). https://doi.org/10.1038/184061a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/184061a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing