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Synthesis of Diphosphopyridine Nucleotide from Nicotinamide by Slices of Liver


FOLLOWING the injection of nicotinamide, large increases in the diphosphopyridine nucleotide content of mouse tissues, particularly liver, have been reported by Kaplan and co-workers1. Although it is thought that diphosphopyridine nucleotide is synthesized from adenine mononucleotide, the increase in the former is accompanied by an increase in the total acid-soluble adenine content of the liver.

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THRELFALL, C. Synthesis of Diphosphopyridine Nucleotide from Nicotinamide by Slices of Liver. Nature 184, 60–61 (1959).

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