Abstract
IN view of the long-continued interest in the relationship of histamine to metabolic processes and disorders, most particularly allergy and psychosis, the present investigation sought to explore the effects of prolonged administration of various tranquillizers on response in the rat to histamine, including effects on such variables as histamine LD50, mortality and alterations in body-weight.
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References
Finney, D. J., “Probit Analysis”, 2nd ed. (Cambridge Univ. Press, Cambridge, 1952).
Gaunt, R., Renzi, A. A., Antonchak, N., Miller, G. J., and Gilman, M., Ann. New York Acad. Sci., 59, 22 (1954).
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SACKLER, A., WELTMAN, A. & SACKLER, R. Effect of Tranquillizing Agents on the Resistance of Rats to Histamine Stress. Nature 183, 896–897 (1959). https://doi.org/10.1038/183896a0
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DOI: https://doi.org/10.1038/183896a0
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