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Study of Adenovirus Antigens by Immunoelectrophoresis

Abstract

MULTIPLICATION of adenoviruses in susceptible cells is accompanied by the formation of antigenic materials which can be distinguished from virus particles. These materials have been detected by different serological techniques including complement fixation1,2, sensitized red-cell agglutination3, conglutinating complement adsorption4 and gel diffusion precipitation5. Part of the non-virus material is responsible for the early cytopathic6 and cell-detaching7 properties which are abolished by incubation with trypsin or by addition of homologous antiserum, a result suggesting that they are mediated by an antigenically specific protein.

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PEREIRA, H., ALLISON, A. & FARTHING, C. Study of Adenovirus Antigens by Immunoelectrophoresis. Nature 183, 895–896 (1959). https://doi.org/10.1038/183895a0

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