Abstract
IT has recently been reported by two of us1,2 that various kinds of experimental atherosclerosis, indicated by great increase in the total cholesterol/lipid phosphorus ratio in the blood and tissues of animals, can be prevented by hydrolysed glucose–cycloacetoacetate, a product formed by condensing glucose with acetoacetate. It was shown by Van Dommeleu and Schutt3 that albumin fraction is low and γ-globulin is high in diabetic coma, and Klinger4 observed that when diabetes is accompanied with severe hypertension, there is a further decrease of albumin and a sharp increase of γ-globulin. As according to Dawber et al. 5 hypertension is usually associated with the incidence of atherosclerosis, attempts were made to study the protein pattern in the serum of saturated fat-induced atherosclerotic animals and in those prevented by essential fatty acids, inositol, vitamin B12 and glucose–cycloacetoacetate (hydrolysed).
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References
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NATH, M., SAIKIA, A. & UPPIN, B. Disturbance in the Pattern of Serum Proteins in Experimental Atherosclerosis and its Prevention. Nature 183, 894–895 (1959). https://doi.org/10.1038/183894a0
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DOI: https://doi.org/10.1038/183894a0
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