Abstract
IT was recently demonstrated that thiosulphate esters rapidly react with protein sulphydryl groups to give mixed disulphides1. As Eldjarn and Pihl2 have attributed the protective properties against radiation of certain sulphur compounds (for example, cysteamine, cystamine) to their ability to form mixed disulphides with active sulphydryl or disulphide groups in the cell, the possibility was considered that thiosulphate esters may be active protectors against ionizing radiation.
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References
Sörbo, B., Acta Chem. Scand., 12, 1990 (1958).
Eldjarn, L., and Pihl, A., J. Biol. Chem., 223, 341 (1956).
Bretschneider, H., Österr. Akad. Wiss., Math.-naturw. Kl. Sitzber., Abt. II, b, 159, 372 (1950).
Miller, L. C., and Tainter, M. L., Proc. Soc. Exp. Biol. Med., 57, 261 (1944).
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HOLMBERG, B., SÖRBO, B. Protective Effect of β-Aminoethylthiosulphuric Acid against Ionizing Radiation. Nature 183, 832 (1959). https://doi.org/10.1038/183832a0
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DOI: https://doi.org/10.1038/183832a0
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