Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Induction of Subcutaneous Nodules in Rabbits with the SE Polyoma Virus

Nature volume 183, pages 766–767 (1959)Cite this article

Abstract

THE SE polyoma virus grown in mouse embryo cell cultures is capable of inducing a wide spectrum of histologically different neoplasms in hybrid (C 3 Hf × AKR)F 1 1 and randomly bred Swiss mice2, and sarcomas and angiomatous lesions in hamsters3, and rats4, if injections are made when the animals are new-born. Tumours in these animals increase in size and number and eventually kill the animals. Contrary to experience with these rodents, new-born rabbits of mongrel breed reacted by developing multiple subcutaneous nodules that later regressed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Stewart, S. E., Eddy, B. E., Gochenour, A. M., Borgese, N. G., and Grubbs, G. E., Virol., 3, 380 (1957).

    Article  CAS  Google Scholar 

  2. Stewart, S. E., Eddy, B. E., and Borgese, N., J. Nat. Cancer Inst., 20, 1223 (1958).

    Article  CAS  Google Scholar 

  3. Eddy, B. E., Stewart, S. E., Young, R., and Mider, G. B., J. Nat. Cancer Inst., 20, 747 (1958).

    CAS  PubMed  Google Scholar 

  4. Eddy, B. E., Stewart, S. E., Stanton, Mearl F., and Marcotte, J. M., J. Nat. Cancer Inst., 22, 161 (1959).

    CAS  PubMed  Google Scholar 

  5. Morgan, J. F., Morton, J. H., and Parker, R. C., Proc. Soc. Exp. Biol. and Med., 73, 1 (1950).

    Article  CAS  Google Scholar 

  6. Eddy, B. E., Stewart, S. E., and Grubbs, G. E., Proc. Soc. Exp. Biol. and Med., 99, 289 (1958).

    Article  CAS  Google Scholar 

  7. Eddy, B. E., Stewart, S. E., and Berkeley, W., Proc. Soc. Exp. Biol. and Med., 98, 848 (1958).

    Article  CAS  Google Scholar 

  8. Eddy, B. E., Rowe, W. P., Hartley, J. W., Stewart, S. E., and Huebner, R. J., Virol., 6, 290 (1958).

    Article  CAS  Google Scholar 

  9. Lillie, R. D., “Histopathologic Technic and Practical Histochemistry”, 2nd edit., 501 (The Blakiston Co., New York, 1954).

    Google Scholar 

  10. Stout, A. D., Cancer, 7, 953 (1954).

    Article  CAS  Google Scholar 

  11. Stewart, S. E., Eddy, B. E., and Stanton, M. F., Canad. Cancer Res. Proc. (in the press).

  12. Eddy, B. E., and Stewart, S. E., Canad. Cancer Res. Proc. (in the press).

Download references

Author information

Authors and Affiliations

  1. Division of Biologies Standards, and National Cancer Institute, Department of Health, Education and Welfare, U.S. Public Health Service,

    BERNICE E. EDDY, SARAH E. STEWART, RUTH L. KIRSCHSTEIN & RALPH D. YOUNG

Authors
  1. BERNICE E. EDDY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SARAH E. STEWART
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. RUTH L. KIRSCHSTEIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. RALPH D. YOUNG
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

EDDY, B., STEWART, S., KIRSCHSTEIN, R. et al. Induction of Subcutaneous Nodules in Rabbits with the SE Polyoma Virus. Nature 183, 766–767 (1959). https://doi.org/10.1038/183766a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/183766a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing