Abstract
SINCE the work described above was carried out we have investigated the reduced inactivation of histamine by liver and brain from mice sensitized with B. pertussis. Histamine was added to a homogenate of the organs. Then the amount of histamine remaining after various intervals of incubation at 37° C. was determined by extracting histamine by a modified McIntire's method1 and using guinea pigileum. The extract responded to atropin and anti-histamines in much the same way as histamine did. The liver and brain of sensitized mice showed a statistically significant reduction in the histamine-inactivating activity over non-sensitized mice.
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References
McIntire, F. C., Roth, L. W., and Shaw, J. L., J. Biol. Chem., 170, 537 (1947).
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MATSUI, T., KISHIGAMI, M. & KUWAJIMA, Y. Reduced Activity of Histaminase in Rats sensitized by Bordetella pertussis . Nature 183, 756 (1959). https://doi.org/10.1038/183756a0
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DOI: https://doi.org/10.1038/183756a0
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