Abstract
THE rate of β-oxidation of γ-substituted butyric acids by washed suspensions of species of soil Nocardia has been found to depend on the nature of the substituents1,2. γ-Phenoxybutyric is oxidized more slowly than γ-phenylbutyric acid, and substitution in the phenoxy group, particularly in the ortho position, further retards the process. γ-Hydroxy acid intermediates were generally formed from γ-aryloxy-butyric acids. It has now been found that the substitution of CH3—for H—on the γ carbon atom of the γ-phenoxybutyric acids further retards β-oxidation.
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References
Webley, D. M., Duff, R. B., and Farmer, V. C., J. Gen. Microbiol., 18, 733 (1958).
Webley, D. M., Duff, R. B., and Farmer, V. C., Nature, 179, 1130 (1957).
Wain, R. L., Sci. Prog., 44, 604 (1956).
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WEBLEY, D., DUFF, R. & FARMER, V. Effect of Substitution in the Side-Chain on β-Oxidation of Aryloxy-alkylcarboxylic Acids by Nocardia opaca . Nature 183, 748–749 (1959). https://doi.org/10.1038/183748a0
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DOI: https://doi.org/10.1038/183748a0
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