Abstract
RELATIVELY little is known regarding the role of the adrenal cortex in human pregnancy. Conflicting reports appear in the literature on steroid excretion-rates in women during normal pregnancy. Some workers1 have found no change in 17-ketogenic steroid excretion in the last trimester of pregnancy, while others2, using the same chemical method for their estimation, report a slight increase in levels. In contrast, Venning3, employing a bioassay technique as a measure of adrenal activity, found an initial rise in excretion of glycogenic corticoids in the first trimester of human pregnancy. This later returned to normal values with a falling-off in excretion-rate usually occurring in the last month. Shortly after parturition the values were back to normal levels again.
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References
Norymberski, J. K., and Stubbs, R. D., Lancet, i, 1276 (1953).
Schüller, E., Acta Endocr., 35, 345 (1957).
Venning, E. H., Endocrinol., 39, 203 (1946).
Bush, I. E., Ciba Foundation Colloquia on Endocrinology, 7, 210 (J. and A. Churchill, Ltd., London, 1953).
Macfarlane, W. V., and Robinson, K. W., J. App. Physiol., 11, 199 (1957).
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ROBINSON, K. Adrenal Cortical Function in the Pregnant Sheep. Nature 183, 690–691 (1959). https://doi.org/10.1038/183690a0
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DOI: https://doi.org/10.1038/183690a0
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