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Ineffectiveness of Molybdenum, Osmium and Cobalt in Dietary Necrotic Liver Degeneration

Abstract

IN our past, comprehensive experience in the fractionation and purification of Factor 3 from various source materials, using the prophylactic rat test against dietary liver necrosis as an assay, it has been obvious that the Factor 3 effect was caused by a highly specific, potent, protective ingredient. The latter was recognized to be an organic selenium compound1; this, in turn, led to the realization that selenium is an essential micronutrient. Selenite-selenium was found to prevent necrotic liver degeneration, with a 50 per cent effective dose-level of 2.2 µgm. per cent and full protection at levels of approximately 5 μgm. per cent selenium in the diet. Factor 3-selenium is 3–5 times as potent2.

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SCHWARZ, K., ROGINSKI, E. & FOLTZ, C. Ineffectiveness of Molybdenum, Osmium and Cobalt in Dietary Necrotic Liver Degeneration. Nature 183, 472–473 (1959). https://doi.org/10.1038/183472a0

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  • DOI: https://doi.org/10.1038/183472a0

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