Abstract
THE ability of penicillin to function as an antigen, or more probably as a haptene, has only recently been described. Using the penicillin-sensitized red cell technique of Ley et al. 1, we have encountered eighteen sera from approximately 1,200 specimens, obtained from hospitalized patients, which have caused hæmagglutination. Preliminary testing was carried out on white porcelain tiles at room temperature using a 5.0 per cent suspension of group O, Rh-negative sensitized cells. Positive sera were titrated in 3 in. × ½ in. tubes at 37.0° C. and at 4.0° C. Control non-sensitized cells were included.
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References
Ley, A. B., Harris, J. P., Brinkley, M., Liles, B., Jack, J. A., and Cahan, A., Science, 127, 1119 (1958).
Smithies, O., Biochem. J., 61, 629 (1955).
Poulik, M. D., and Smithies, O., Biochem. J., 68, 636 (1958).
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WATSON, K., JOUBERT, S. & BENNETT, M. Penicillin as an Antigen. Nature 183, 468–469 (1959). https://doi.org/10.1038/183468a0
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DOI: https://doi.org/10.1038/183468a0
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