Abstract
CYCLOHEXIMIDE, an antibiotic with selective inhibitory effect on many fungi1,2 but inactive against bacteria, has received increased attention during recent years, but few reports are concerned with its mode of action. Cycloheximide inhibits aerobic utilization of many intermediates of carbohydrate metabolism by Tetrahymena pyriformis 3, and it is active against higher plants4. Kerridge5 has observed that fungistatic doses of cycloheximide (0.5–1.0 µgm./ml.) have no marked effect on fermentation and respiration of Saccharomyces mandshuricus, but synthesis of protein and deoxyribonucleic acid is completely blocked. On the other hand, Greig et al. 6 have recently announced that in the case of Saccharomyces cerevisiae the same antibiotic shows an inhibitory effect on fermentation.
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BLUMAUEROVÁ, M., STÁRKA, J. Reversal of Antibiotic Action of Cycloheximide (Actidione) by Bivalent Metal Ions. Nature 183, 261 (1959). https://doi.org/10.1038/183261a0
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DOI: https://doi.org/10.1038/183261a0
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