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Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations


THE work reported here stemmed from the experiments described in an earlier communication1 on p-aminobenzylpenicillin, in which discrepancies were observed between chemical and biological methods of penicillin assay when a precursor was omitted from penicillin fermentations.

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BATCHELOR, F., DOYLE, F., NAYLER, J. et al. Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations. Nature 183, 257–258 (1959).

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