Abstract
IN 1956 a survey of hæmoglobin types in Liberians by Robinson, Zuelzer, Neel, Livingstone and Miller led to the discovery of two ‘fast-moving’ hæmoglobins which were provisionally designated Liberian I and II, the first abnormal complement moving on electrophoresis at pH 8.6 faster than the second and both moving faster than normal adult hæmoglobin A. Liberian I was at first supposed to be identical with hæmoglobin J discovered by Thorup, Itano, Wheby and Leavell1; but further study by Ager and Lehmann2 demonstrated a difference in the behaviour of these hæmoglobins, Liberian I migrating faster than J at alkaline pH, though slower than H or I. At acid pH Liberian I separates from A towards the anode while J does not. Liberian I, thus being a new hæmoglobin, was called hæmoglobin N.
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References
Thorup, O. A., Itano, A. H., Wheby, M., and Leavell, B. S., Science, 123, 889 (1956).
Ager, J. A. M., and Lehmann, H., Brit. Med. J., i, 929 (1958).
Robinson, A. R., Zuelzer, W. W., Neel, J. V., Livingstone, F. B., and Miller, M. J., Blood, 11, 902 (1956).
Trincão, C., de Almeida Franco, L. T., Gomes, M. P. N. C., and Ferreira, N. C., Sangre, 3, 55 (1958).
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TRINCÂO, C., DE ALMEIDA FRANCO, L. & NOGUEIRA, A. Hæmoglobin N in Portuguese Guinea. Nature 183, 193–194 (1959). https://doi.org/10.1038/183193a0
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DOI: https://doi.org/10.1038/183193a0
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