Abstract
THE heterogeneity of serum albumins consisting of several molecular sub-units has been established by chemical as well as by electrophoretic assays. However, while chemical fractionation of serum albumins led to well-identified products, electrophoretic procedures did not show equally consistent results. In this latter case, the separation of the sub-units was found to vary with pH, ionic strength, length of run, and other factors not well understood1. It could be shown, moreover, that the splitting of albumin into a number of boundaries is a reversible process and does not represent denaturation on artefacts.
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References
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ANNAU, E. Splitting of the Electrophoretic Pattern of Serum Albumin during Short-term Action of Pepsin at Room Temperature. Nature 183, 190–191 (1959). https://doi.org/10.1038/183190b0
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DOI: https://doi.org/10.1038/183190b0
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