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Sparing Effect of Serum from Mice treated with Endotoxin upon Certain Murine Virus Diseases

Nature volume 183, pages 185–186 (1959)Cite this article

Abstract

BACTERIAL endotoxin has a complex pharmacological action upon animals; this includes a febrile response beginning about 2 hr. after its intravenous or intraperitoneal inoculation. Blood serum from dogs1 and rabbits2 2 hr. after the inoculation of endotoxin contains a pyrogen distinct from endotoxin3,4. It has been termed ‘endogenous pyrogen’ and is believed to be produced by damaged cells, notably leucocytes. Indeed, it has been suggested that cells damaged in ways other than by endotoxin produce endogenous pyrogen and that endogenous pyrogen may be the factor common to fevers of diverse etiology4.

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  1. National Institute for Medical Research, Mill Hill, London, N.W.7.

    A. W. GLEDHILL

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  1. A. W. GLEDHILL
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GLEDHILL, A. Sparing Effect of Serum from Mice treated with Endotoxin upon Certain Murine Virus Diseases. Nature 183, 185–186 (1959). https://doi.org/10.1038/183185a0

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