Effect of Insulin and Phenazine Methosulphate on Pathways of Glucose Catabolism in the Mammary Gland of the Rat

Abstract

THERE is considerable evidence that a large part of the glucose catabolism of the lactating mammary gland of the rat occurs by way of the pentose phosphate pathway¹. The effect of insulin on the relationship between glucose utilization and fatty acid synthesis has recently been investigated by Abraham et al. ², who have shown that the addition of insulin to mammary gland slices from lactating rats caused an increased production of carbon dioxide labelled with carbon-14 from (1⁻¹⁴C)glucose and an increased incorporation of glucose carbon into fatty acids.