Abstract
DURING routine blood-group examination of healthy persons, one of the blood samples tested was found to exhibit unusual properties. The potent anti-A and anti-B test sera used agglutinated the erythrocytes quite well, whereas the serum of this AB blood (subgroup A2B) reacted weakly at room temperature with B cells. The irregular agglutinin was no more active at 37° C. and reacted better at 4° C. (titre 8) than at 20° C. No auto-agglutination was observed. At 4° C. the serum agglutinated all of 15 B but neither 20 A nor 15 O cells samples simultaneously tested. The B specificity of this agglutinin was confirmed by absorption experiments with B erythrocytes and with purified blood group B substance. The B specificity of the agglutinogen in Mrs. Br.'s cells was ascertained by studying the action of several A and AB sera on them; the agglutinating action of A sera did not occur after absorption by normal B cells or purified B substance. The ‘Br.’ cells significantly absorbed the anti-B agglutinin in normal A sera, but less, however, than did A2B cells used as control, and released it after elution more completely than did these A2B cells. The ‘Br.’ cells were agglutinated by anti-H eel serum nearly as well as group O cells. The ‘Br.’ saliva inhibited the anti-A agglutinin at a high dilution, and the anti-B and anti-H agglutinins when more concentrated. Its inhibitory action on anti-H was not weaker than that of an A2 control.
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MOULLEC, J., LE CHEVREL, P. A Rare Variant of B in a Human Blood Sample belonging to Group AB. Nature 183, 1733 (1959). https://doi.org/10.1038/1831733a0
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DOI: https://doi.org/10.1038/1831733a0
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