Abstract
THE relation between the long-term effects of radiation and ageing has been the subject of much investigation in recent years, but little quantitative work has been done on the variation with age of the effects produced by a given dose of radiation. Using a single dose, Abrams1 found a maximum mortality-rate in mice 4 weeks old. Hursh and Casarett2 measured the LD50 in rats of different ages, and found a decrease with age in the latter period of life ; somewhat similar results were obtained by Sacher3 for mice. We are carrying out a systematic study4 of the long-term effects of radiation in mice, with particular reference to the dependence of these effects on age. As part of this work, we have investigated the variation of sensitivity with age, using as a criterion of radiation damage the LD50 at 30 days.
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References
Abrams, H. L., Proc. Soc. Exp. Biol. Med., 76, 729 (1951).
Hursh, J. B., and Casarett, G. V., Brit. J. Radiol., 39, 169 (1956).
Sacher, G. A., Science, 125, 1039 (1957).
Lindop, P. J., and Rotblat, J., Second Geneva Conference on Peaceful Uses of Atomic Energy (1959).
Blair, H. D., First Geneva Conference on Peaceful Uses of Atomic Energy, 11, 118 (1956).
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CROSFILL, M., LINDOP, P. & ROTBLAT, J. Variation of Sensitivity to Ionizing Radiation with Age. Nature 183, 1729–1730 (1959). https://doi.org/10.1038/1831729a0
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DOI: https://doi.org/10.1038/1831729a0
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