Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Serum Transferrins

Abstract

GENETICALLY controlled variations in the β-globulins of normal human and cattle sera have recently been demonstrated by starch-gel electrophoresis1–6. Evidence has been presented7 suggesting that the variable β-globulins in man are iron-binding serum proteins (transferrins). We have confirmed this directly by demonstrating with autoradiographs that iron-59 is bound specifically to the variable β-globulins in human sera, and also in cattle sera. The variable serum β-globulins in man and cattle are thus transferrins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Smithies, O., Nature, 180, 1482 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Horsfall, W. R., and Smithies, O., Science, 128, 35 (1958).

    Article  ADS  CAS  Google Scholar 

  3. Smithies, O., Nature, 181, 1203 (1958).

    Article  ADS  CAS  Google Scholar 

  4. Harris, H., Robson, E. B., and Siniscalco, M., Nature, 182, 452 (1958).

    Article  ADS  CAS  Google Scholar 

  5. Smithies, O., and Hickman, C. G., Genetics, 43, 374 (1958).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Ashton, G. C., Nature, 182, 370 (1958).

    Article  ADS  CAS  Google Scholar 

  7. Smithies, O., and Hiller, O., Biochem. J. (in the press).

  8. Smithies, O., Biochem. J., 71, 585 (1959).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GIBLETT, E., HICKMAN, C. & SMITHIES, O. Serum Transferrins. Nature 183, 1589–1590 (1959). https://doi.org/10.1038/1831589a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1831589a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing