Abstract
A SYSTEM of inherited serum groups has been described by Grubb and Laurell1. Sera from certain patients with rheumatoid arthritis agglutinated Rh-positive red cells which had been coated with selected incomplete anti-D. The agglutination was inhibited by sera from about 60 per cent of normal individuals, who were said to be Gm(a+) because the inhibiting substance was located in the gamma-globulin fraction of serum. This substance was inheritable, determined by the gene Gma, which expressed itself in single or double dose. The corresponding allele was called Gm.
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References
Grubb, R., and Laurell, A.-B., Acta Path. Microbiol. Scand., 39, 390 (1956).
Harboe, M., and Lundevall, J., Acta Path. Microbiol. Scand., 45, 357 (1959).
Stratton, F., and Renton, P. H., “Practical Blood Grouping” (Oxford, 1958).
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HARBOE, M. A New Hæmagglutinating Substance in the Gm System, Anti-Gm. Nature 183, 1468–1469 (1959). https://doi.org/10.1038/1831468a0
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DOI: https://doi.org/10.1038/1831468a0
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