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Excessive Uric Acid Production in the Human induced by 2-Ethylamino-1,3,4-thiadiazole

Abstract

AN excessive endogenous synthesis of uric acid is present in a substantial portion of patients with gout1. The precise nature of the metabolic defect responsible for such excessive production is not known, but may be the result of a defective homœostatic mechanism for control of purine synthesis. Evidence for the existence of such a mechanism in the normal human has come from the observation2 that the simultaneous administration of 4-amino-5-imidazolecarboxamide suppresses de novo purine biosynthesis from glycine-15N. Factors affecting uric acid synthesis in the human are therefore of special interest in regard to the study of gout.

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References

  1. Benedict, J. D., Yü, T. F., Bien, E. J., Gutman, A. B., and Stetten, jun., DeW., J. Clin. Invest., 32, 775 (1953). Seegmiller, J. E., Laster, L., and Liddle, L. V., Metabolism, 7, 376 (1958). Gutman, A. B., Yü, T. F., Black, H., Yalow, R. S., and Berson, S. A., Amer. J. Med., 25, 917 (1958).

    Article  CAS  Google Scholar 

  2. Seegmiller, J. E., Laster, L., and Stetten, jun., DeW., J. Biol. Chem., 216, 653 (1955).

    CAS  PubMed  Google Scholar 

  3. Krakoff, I. H., and Magill, G. B., Proc. Soc. Exp. Biol. Med., 91, 470 (1956).

    Article  CAS  Google Scholar 

  4. Gold, G. L., and Fritz, R. D., Ann. Int. Med., 47, 428 (1957).

    Article  CAS  Google Scholar 

  5. Wyngaarden, J. B., J. Clin. Invest., 36, 1508 (1957).

    Article  CAS  Google Scholar 

  6. Shapiro, D. M., Shils, M. E., Fugmann, R. A., and Friedland, I. M., Cancer Res., 17, 29 (1957).

    CAS  Google Scholar 

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SEEGMILLER, J., GRAYZEL, A. & LIDDLE, L. Excessive Uric Acid Production in the Human induced by 2-Ethylamino-1,3,4-thiadiazole. Nature 183, 1463–1464 (1959). https://doi.org/10.1038/1831463a0

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