Abstract
THE microbiological steroid transformations in the preparation of sex- and adrenocortical hormones opened a new field for the use of micro-organisms in organic synthesis. An interesting feature of these reactions is the ability to transform substances which are practically insoluble in water in an aqueous medium. It seems obvious that this transformation does not take place in the aqueous phase itself but on the lipoid surface of the micro-organisms. When the fermentation broth and the mycelial mass are treated separately after such transformations, the fermentation broth contains relatively more polar transformation product and less starting material, whereas considerable quantities of the initial steroids could be recovered from the mycelial mass.
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References
Peterson, D. H., and Murray, H. C., U.S. Patent 2,602,769 (July 8, 1952).
Albrecht, K., and Wix, Gy., Magyar Kémiai Folyóirat, 64, 237 (1958).
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Wix, G., ALBRECHT, K. A New Method for the Microbiological Oxidation of Steroids. Nature 183, 1279–1280 (1959). https://doi.org/10.1038/1831279a0
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DOI: https://doi.org/10.1038/1831279a0
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