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Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours


DESPITE many investigations of royal jelly1, its chemistry and pharmacological activity have not been completely established. As part of a long-term study on the chemistry and biological activity of royal jelly2 we have recently investigated its possible anti-tumour properties. In this communication we wish to report that admixture of royal jelly with tumour cells before inoculation completely suppresses the development of a transplantable mouse leukæmia and the formation of ascitic tumours in mice. Fractionation studies have established that this anti-tumour activity resides in the main fatty acid of the royal jelly—10-hydroxydecenoic acid.

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TOWNSEND, G., MORGAN, J. & HAZLETT, B. Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours. Nature 183, 1270–1271 (1959).

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