Abstract
SIMULTANEOUS administration of choline and inositol to rats prevents the formation of fatty liver to a greater extent than if either substance were given alone1. There have also been several isolated reports which suggest to us the existence of an antagonism between choline and inositol. Suppression by choline of the growth of yeast requiring inositol has been reported by Taylor and McKibbin2. The addition of choline depressed growth under conditions in which growth was limited by the concentration of inositol in the incubation medium. Also, in studies of renal necrosis found in developing rats fed a diet deficient in choline, Handler3 observed that the addition of inositol to that diet greatly aggravated the renal necrosis, while it reduced the degree of liver fat in the same animals.
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References
Forbes, J. C., Proc. Soc. Exp. Biol. and Med., 54, 89 (1943).
Taylor, W. E., and McKibbin, J. M., Proc. Soc. Exp. Biol. and Med., 79, 95 (1952).
Handler, P., J. Nutrition, 31, 621 (1946).
Jukes, T. M., Poultry Sci., 20, 251 (1941).
Kennedy, E. P., Fed. Proc., 16, 847 (1957).
Agranoff, B. W., and Bradley, R. M., Fed. Proc., 17, 179 (1958).
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AGRANOFF, B., SPIVEY FOX, M. Antagonism of Choline and Inositol. Nature 183, 1259–1260 (1959). https://doi.org/10.1038/1831259a0
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DOI: https://doi.org/10.1038/1831259a0
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