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Effect of Toxopyrimidine on Glutamic-decarboxylase and Glutamic-oxalacetic Transaminase of Rat Brain

Abstract

IN a previous communication Rindi and Ferrari1 reported a statistically significant decrease of γ-aminobutyric acid in the brain of rats treated with a structural pyridoxamine antagonist having an epileptogenic action, namely, 2-methyl,4-amino,5-oxymethylpyrimidine (toxopyrimidine). In this communication we wish to report results obtained in an enzymatic study of the action of toxopyrimidine. We determined the glutamic decarboxylase and glutamic-oxalacetic transaminase (both pyridoxal-phosphate linked enzymes) in the brain of rats with epileptic seizures caused by injection of toxopyrimidine, and of rats restored to normal with pyridoxamine.

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RINDI, G., PERRI, V. & VENTURA, U. Effect of Toxopyrimidine on Glutamic-decarboxylase and Glutamic-oxalacetic Transaminase of Rat Brain. Nature 183, 1126–1127 (1959). https://doi.org/10.1038/1831126a0

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  • DOI: https://doi.org/10.1038/1831126a0

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