Abstract
IT has been found by Hitchings et al. 1 that 2 : 4-diamino-6-alkylpyrimidines which have bulky substituents (for example, phenyl) at C5 are strong folic acid antagonists, some of which have marked anti-malarial2 and antileukæmic properties3. Furthermore, Curd, Rose and their co-workers had shown previously that many 6-alkylpyrimidines having substituted amino-groups at C2 and C4 were active as antimalarials4.
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References
Hitchings, G. H., Falco, E. A., Vanderwerff, H., Russell, P. B., and Elion, G. B., J. Biol. Chem., 199, 43 (1952).
Falco, E. A., Goodwin, L. G., Hitchings, G. H., Rollo, I. M., and Russell, P. B., Brit. J. Pharmacol., 6, 185 (1951).
Burchenal, J. H., Goetchins, S. K., Stock, C. C., and Hitchings, G. H., Cancer Res., 12, 255 (1952).
Rose, F. L., J. Chem. Soc., 2770 (1951).
“Methods of Vitamin Assay”, 2nd edit. (Interscience Pub., Inc., 1951).
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GHOSH, S., ROY, D. & GUHA, B. Arylaminopyrimidines as Growth-Inhibitors of Streptococcus faecalis and Lactobacillus arabinosus . Nature 182, 187–188 (1958). https://doi.org/10.1038/182187a0
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DOI: https://doi.org/10.1038/182187a0
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