Arylaminopyrimidines as Growth-Inhibitors of Streptococcus faecalis and Lactobacillus arabinosus

Abstract

IT has been found by Hitchings et al. 1 that 2 : 4-diamino-6-alkylpyrimidines which have bulky substituents (for example, phenyl) at C5 are strong folic acid antagonists, some of which have marked anti-malarial2 and antileukæmic properties3. Furthermore, Curd, Rose and their co-workers had shown previously that many 6-alkylpyrimidines having substituted amino-groups at C2 and C4 were active as antimalarials4.

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References

  1. 1

    Hitchings, G. H., Falco, E. A., Vanderwerff, H., Russell, P. B., and Elion, G. B., J. Biol. Chem., 199, 43 (1952).

  2. 2

    Falco, E. A., Goodwin, L. G., Hitchings, G. H., Rollo, I. M., and Russell, P. B., Brit. J. Pharmacol., 6, 185 (1951).

  3. 3

    Burchenal, J. H., Goetchins, S. K., Stock, C. C., and Hitchings, G. H., Cancer Res., 12, 255 (1952).

  4. 4

    Rose, F. L., J. Chem. Soc., 2770 (1951).

  5. 5

    “Methods of Vitamin Assay”, 2nd edit. (Interscience Pub., Inc., 1951).

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GHOSH, S., ROY, D. & GUHA, B. Arylaminopyrimidines as Growth-Inhibitors of Streptococcus faecalis and Lactobacillus arabinosus . Nature 182, 187–188 (1958). https://doi.org/10.1038/182187a0

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