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Isolation of Δ5,7,9-Œstratrienol-3-one-17 from the Urine of Pregnant Mares

Abstract

Δ5,7,9-ŒSTRATRIENOL-3-one-17 was isolated from pregnant mares' urine in 1940 by Heard and Hoffman1. These workers obtained approximately 160 mgm. of pure material per 10,000 gallons of urine, that is, about 3.8 µgm./l., but stated that this did not represent the total quantity excreted. Since no other isolations of Δ5,7,9-œstratrienol-3-one-17 from pregnant mares' urine have been reported in the literature, we believe that it is of interest to record that we have found the material to be present in pregnant mares' urine in relatively large quantities (approximately 430 gm. of Δ5,7,9-œstratrienol-3-one-17 per 10,000 gallons of urine, that is, about 10 mgm./l.) and that we have isolated the material readily in the pure state.

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References

  1. Heard, R. D. H., and Hoffman, M. M., J. Biol. Chem., 135, 801 (1940).

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  2. Glen, W L., Barber, R., and Grant, G. A., Nature, 180, 288 (1957).

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GLEN, W., BARBER, R. & PAPINEAU-COUTURE, G. Isolation of Δ5,7,9-Œstratrienol-3-one-17 from the Urine of Pregnant Mares. Nature 182, 1308–1309 (1958). https://doi.org/10.1038/1821308b0

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