Abstract
RECENTLY, Comb and Roseman1 observed that N-acetyl-d-mannosamine and not N-acetyl-d-glucosamine was a substrate for the enzyme synthesizing N-acetylneuraminic acid (nanaldolase) isolated from Clostridium perfringens. These results seem to be in conflict with the synthesis of N-acetylneuramic acid from N-acetyl-d-glucosamine as reported by Corn-forth, Firth and Gottschalk2. The observations of Comb and Roseman suggest that N-acetyl-d-mannosamine should be the starting product for the synthesis of N-acetylneuraminic acid.
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References
Comb, D. G., and Roseman, S., J. Amer. Chem. Soc., 80, 497 (1958).
Cornforth, J. W., Firth, M. E., and Gottschalk, A., Biochem. J., 68, 57 (1958).
Walop, J. N., Abstract of communications to 4th Int. Congress of Biochem. Vienna (1958).
Cardini, C. E., and Leloir, L. F., J. Biol. Chem., 225, 317 (1957).
Comb, D. G., and Roseman, S., J. Amer. Chem. Soc., 80, 3166 (1958).
Gottschalk, A., Nature, 176, 881 (1955).
Kuhn, R., and Brossmer, R., Chem. Ber., 89, 2471 (1956).
Zilliken, F., and Glick, M. C., Naturwiss., 43, 536 (1956).
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BRUG, J., PAERELS, G. Configuration of N-acetylneuraminic Acid. Nature 182, 1159–1160 (1958). https://doi.org/10.1038/1821159b0
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DOI: https://doi.org/10.1038/1821159b0
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