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Water Activity of Mammalian Tissues

Nature volume 182, pages 60–61 (1958)Cite this article

Abstract

SINCE the original report by Sabbatani1 that the freezing-point depression of various dog tissues is on the average 150 per cent greater than that of blood, there has been continued interest in the possibility that intracellular fluid is hypertonic to extracellular fluid. Collip2, Leövey and Kerpel-Fronius3, Gömöri and Molnár4, and Pichotka et al. 5 all confirmed Sabbatani's findings, as did Opie6 using melting-point depression.

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References

  1. Sabbatani, L., J. Physiol. Path. Gen., 3, 939 (1901).

    Google Scholar 

  2. Collip, J. B., J. Biol. Chem., 42, 221 (1920).

    CAS  Google Scholar 

  3. Leövey, F., and Kerpel-Fronius, E., Arch. Exp. Path. Pharmakol., 159, 236 (1931).

    Article  Google Scholar 

  4. Gömöri, P., and Molnár, S., Arch. Exp. Path. Pharmakol., 167, 459 (1932).

    Article  Google Scholar 

  5. Pichotka, J., Höfler, W., and Reissner, J., Arch. Exp. Path. Pharmakol., 223, 217 (1954).

    CAS  Google Scholar 

  6. Opie, E. L., J. Exp. Med., 99, 29 (1954).

    Article  CAS  Google Scholar 

  7. Conway, E. J., and McCormack, J. I., J. Physiol., 120, 1 (1953).

    Article  CAS  Google Scholar 

  8. Conway, E. J., Geoghegan, H., and McCormack, J. I., J. Physiol., 130, 427 (1955).

    Article  CAS  Google Scholar 

  9. Brodsky, W. A., Appelboom, J. W., Dennis, W. H., Rehm, W. S., Miley, J. F., and Diamond, I., J. Gen. Physiol., 40, 183 (1956).

    Article  CAS  Google Scholar 

  10. Buckley, K. A., Conway, E. J., and Ryan, H. C., J. Physiol. (in the press).

  11. Appelboom, J. W., Fed. Proc., 16, 278 (1957).

    Google Scholar 

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Author information

Author notes

  1. LEROY H. MAFFLY: Postgraduate Research Fellow of the National Science Foundation.

Authors and Affiliations

  1. Departments of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, 14, Massachusetts

    LEROY H. MAFFLY & ALEXANDER LEAF

  2. the Howard Hughes Medical Institute,

    LEROY H. MAFFLY & ALEXANDER LEAF

Authors
  1. LEROY H. MAFFLY
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  2. ALEXANDER LEAF
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MAFFLY, L., LEAF, A. Water Activity of Mammalian Tissues. Nature 182, 60–61 (1958). https://doi.org/10.1038/182060a0

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