Abstract
FORTY-FOUR mature male albino rats weighing 150–180 gm. were divided into four equal groups. Two of these groups were kept at a temperature of 18° C., while the other two groups were maintained at 35° C. One group maintained at each temperature was kept continuously in light of intensity 30 ft.-candles, and the other groups were kept in darkness. After 12 days the animals were killed by decapitation under light ether anæsthesia, and their blood was collected. The levels of thyroid and thyrotrophic hormone in their serum was determined by the use of the stasis tadpole method1. The tadpoles were divided into five groups, each of twenty animals. A control group was injected with saline. The other groups of tadpoles were injected on alternate days with five injections of 0.02 ml. of serum obtained from the four groups of rats. Increase in length of the hindlimbs of the tadpole was the criterion of thyroid hormone concentration, while the increase in thyroid epithelial cell height was used as an index of thyrotrophic hormone-level in the serum of rats. The thyroids of the rats were examined histologically. They were fixed in Zenker without acetic acid and stained with Mallory's stain2. Analyses of variance and of correlation were performed.
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References
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SOLIMAN, F., BADAWI, H. & GHANEM, Y. Influence of Temperature and Light on Thyroid Function. Nature 182, 57 (1958). https://doi.org/10.1038/182057a0
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DOI: https://doi.org/10.1038/182057a0
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