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Metabolic Role of Xanthopterin


ALBERT1 has suggested that xanthopterin would be found in higher amounts in neoplastic tissues than in normal. In anticipation of confirming this by direct experiment, we have analysed for their pterin content, normal kidney tissue of the golden hamster and transplantable neoplasms in the golden hamster, derived from stilbœstrol-induced renal tumours2. No xanthopterin could be found. The largest amount of tissue used was 1 gm. of normal tissue and 8 gm. of neoplastic tissue, and the smallest amount of xanthopterin that could be detected by the paper chromatographic technique used was 0.l µgm.

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    Albert, A., Biochem. J., 65, 124 (1957); 57, x (1954).

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    Horning, E. S., Z. Krebsforschung, 61, 1 (1956).

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    Koschara, W., Hoppe Seylers Z., 240, 127 (1936).

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    Wieland, H., and Liebig, R., Ann., 555, 146 (1944). Kalckar, H. M., Kjeldgaard, N. O., and Klenow, H., Biochim. Biophys. Acta, 5, 575 (1950).

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    Haddow, A. C., “Chemistry and Biology of Pteridines”, 101 (J. and A. Churchill, London, 1954).

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    Blair, J. A., Biochem. J. (in the press).

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    Slavik, K., Dvorakova, A., and Slavikova, V., Chem. listy, 51, 1536 (1957).

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