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Influence of 4-Methyl-2-thiouracil on the Teratogenic Activity of Hypervitaminosis-A


IT has previously been reported that the incidence of deformities of the skull, brain and palate in the young of female rats exposed to the effects of hypervitaminosis-A during pregnancy is greatly increased if large quantities of cortisone are given to the dams during the period of vitamin A administration1,2. It has also been shown that this ‘potentiating’ action of cortisone in relation to hypervitaminosis-A can be abolished by the administration of insulin to the pregnant female3.

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  1. 1

    Millen, J. W., and Woollam, D. H. M., Brit. Med. J., ii, 196 (1957).

  2. 2

    Woollam, D. H. M., and Millen, J. W., Brit. Med. J., ii, 197 (1957).

  3. 3

    Millen, J. W., and Woollam, D. H. M., Proc. Anat. Soc. (Nov. 1957).

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