Abstract
IT has previously been reported that the incidence of deformities of the skull, brain and palate in the young of female rats exposed to the effects of hypervitaminosis-A during pregnancy is greatly increased if large quantities of cortisone are given to the dams during the period of vitamin A administration1,2. It has also been shown that this ‘potentiating’ action of cortisone in relation to hypervitaminosis-A can be abolished by the administration of insulin to the pregnant female3.
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References
Millen, J. W., and Woollam, D. H. M., Brit. Med. J., ii, 196 (1957).
Woollam, D. H. M., and Millen, J. W., Brit. Med. J., ii, 197 (1957).
Millen, J. W., and Woollam, D. H. M., Proc. Anat. Soc. (Nov. 1957).
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WOOLLAM, D., MILLEN, J. Influence of 4-Methyl-2-thiouracil on the Teratogenic Activity of Hypervitaminosis-A. Nature 181, 992–993 (1958). https://doi.org/10.1038/181992a0
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DOI: https://doi.org/10.1038/181992a0
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