Abstract
IMMUNOCHEMICAL studies carried out by D'Alessandro et al. 1 on a non-pathogenic, culturable treponeme, the so-called Reiter treponeme, revealed the presence of four antigenic components: (1) a thermolabile protein; (2) a specific, thermostable antigen with polysaccharide characteristics; (3) a lipoid, corresponding to the ubiquitous lipidic antigen cardiolipin; (4) another lipoid similar to the organ-specific cerebral antigen of Witebsky2. These studies led to the conclusion that the treponemes, like other organisms, are mosaics of antigens, and a safe basis was established for a better understanding of the complex serological response of the infected host.
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References
D'Alessandro, G., Oddo, F. G., Comes, R., and Dardanoni, L., Riv. Ist. Sierot. Ital., 24, 134 (1949).
Witebsky, E., Münch. med. Wochenschr., 1914 (1927).
Dardanoni, L., and Censuales, S., Riv. Ist. Sierot. Ital., 32, 483 (1957).
Portnoy, J., and Magnuson, H., J. Immunol., 75, 348 (1955).
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D'ALESSANDRO, G., DEL CARPIO, C. A Lipopolysaccharide Antigen of the Treponema . Nature 181, 991–992 (1958). https://doi.org/10.1038/181991b0
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DOI: https://doi.org/10.1038/181991b0
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